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It’s been more than 50 years since a seminal essay in Harper’s Magazine described the “paranoid style” in American politics, but the 2020 election—from baseless allegations of electoral fraud to QAnon’s theory of a liberal cabal engaging in child abuse and cannibalism—made it feel very relevant.

This week, in the days after a pro-Trump mob stormed the U.S. Capitol seeking to overturn the election, dozens of corporations announced that they would halt or suspend donations to the Republican members of Congress who voted against certifying the votes.The move comes amid long-mounting pressure on brands to disclose and own their political contributions and corporate social responsibility activities.

Despite centuries of advancements in the study of medicine and design of biotherapeutics, the human body itself poses one of the biggest challenges to targeting disease treatments to the central nervous system: the blood-brain barrier.